Precision, Safety, & Speed: UniSpray for Acute, Crisis & Emergency Nasal Drug Administration
Published: 25/07/2025
Nasal drug delivery offers a non-invasive alternative that empowers patients to self-administer medication quickly and conveniently, eliminating the need for healthcare professional intervention typically required with injectables. The needle-free nature of nasal devices improves patient acceptance, which in turn fosters better adherence and compliance, and can ultimately improve therapeutic outcomes.
The nasal drug delivery field is experiencing significant evolution with growing interest and further research on targeting the nasal turbinates – highly vascularized structures with extensive surface area – to facilitate efficient systemic drug delivery via the nasal route.
An expanding range of systemically acting drugs have been successfully formulated as non-invasive metered unit-dose nasal sprays, enabling rapid and user-friendly administration with fast-onset of therapeutic action. Examples include naloxone in Narcan® and nalmefene in OPVEE® for opioid overdose; epinephrine in Neffy® for anaphylactic shock; and Zavegepant in Zavzpret™ for migraine relief. These patient-centric medicines, enable patients and caregivers to administer one-shot sprays easily and rapidly to manage emergency and crisis situations, such as overdoses, seizures and migraines.
UniSpray, Nemera’s single-dose nasal spray device, delivers a metered 100μL dose, and provides a platform solution for new, repurposed, or generic drug formulations. Designed for acute, crisis and emergency use, UniSpray is a ready-to-use, primeless device featuring 360° actuation and ergonomic one-handed operation, ensuring ease and reliability under critical conditions.
To ensure device reliability and robustness, as well as compliance with regulatory requirements, UniSpray has undergone comprehensive human factors studies, design verification and rigorous processes, assuring both patient safety and ease of use. The device has an ergonomic and intuitive design to ensure its correct use. Upon activation, the device’s plunger locks securely, preventing accidental re-use and providing a clear visual confirmation that the dose has been delivered – an essential safety feature for emergency administration. The final locking also prevents device disassembly after activation.
UniSpray is compatible with existing marketed primary drug containers and has been adapted to fit conventional filling lines. It also provides a customizable platform, offering flexibility for spray adjustment for reposed drugs, new formulations, and generics. Regulatory agencies enforce stringent standards for nasal drug-device combination therapies, demanding specific performance reliability criteria and in the case of generics – bioequivalence to the original market reference form – both aspects are particularly critical for life-saving therapies – to guarantee patient safety and therapeutic efficacy. UniSpray is compliant with the FDA’s strict reliability specifications for rescue and emergency medicines. In addition...
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